Florence’s eBinders™

The most adopted eISF in clinical research. Florence eBinders digitizes investigator site files and regulatory binders, eliminating paper based processes with structured regulatory workflows designed for sites.

70% site adoption, more than 3x the next-best platform.

See how it works

Simplify Regulatory Work. Stay Inspection Ready.

Replace paper based regulatory binders with configurable eISF workflows that standardize document creation, review, approvals, filing, version control, and audit history across every study.

  • Role Based Permissions

  • Document Version Control

  • Complete Audit Trails

  • Part 11 & Annex 11 eSignatures

  • Digital Regulatory Logs

  • Long-term Archiving

Standardize Every Study from Day One

Reduce study setup time with centralized administration tools that standardize eISF and regulatory binder templates, permissions, task management, reporting, and workflows across every site.

  • Control and standardize eISF templates and naming conventions based on your workflows and SOPs

  • Customize granular access and permissions for your entire study team and external users

  • Create placeholders, due dates and task assignments to keep studies progressing

  • Identify risk areas with advanced reporting and dashboards

 Source Documents Without the Manual Work

Eliminate manual document collection with secure integrations, automated source capture, built in PHI protection, and encrypted document exchange between clinical systems.

  • Integrate with your CTMS and EMR/EHR system to route certified copies to participant binders

  • Built-in redaction controls ensure only authorized users see Protected Health Information (PHI)

  • Florence ePrinter enables secure, encrypted digital exchange of sensitive documents between clinical systems

Keep Sites, Sponsors, and Monitors Aligned

Reduce delays and duplicate work with secure document sharing, structured review workflows, visit management, and real time monitoring activity in one shared workspace.

  • Pre Visit Document Review

  • Redacted Binder Access

  • Visit Scheduling

  • Monitor Activity Tracking

Why 65,000+ Sites Choose Florence

Site First

Designed around how sites actually execute regulatory work, aligned to your SOPs, staffing models, and daily workflows.

Inspection Readiness

Maintain always on compliance with embedded audit trails, version control, and compliant eSignatures built directly into daily workflows.

Real-Time Collaboration

Work with sponsors and monitors in one shared system, eliminating duplicate uploads and manual reconciliation.

Eliminate paper and take control of your regulatory workflows.

Real success, real stories

“We love the ability to set up regulatory files just like we would in paper format. Importing is so easy, as is sending out requests for signatures.”

– Mark Sulik, PharmD CCRP, Director of Clinical Research

  • 20-30+ hours saved per week

  • Smooth transition from paper to digital workflows

  • Faster document circulation and signatory capture

  • Reduced signature wait time from over a week to under an hour

  • Accelerated staff onboarding from weeks to days

  • Supports 1,200+ MCW and affiliate users, plus 1,000+ external monitors

  • Enhanced document organization and standardized processes, improving efficiency and reducing duplication across multiple studies

“Operationally, digital collaboration brings about so much improvement it is well worth every dollar that you invest in it.”

– Chad Adams, Associate Director of Research Administration

  • 100% elimination of paper shadow-charts and binder rooms

  • eCRF workflows across reg and clinical teams

  • ePrinter capturing all source data from EMR

Florence is used to support over 10 million monitoring workflows per month across 65k study sites in 90+ countries.

  • 30 studies onboarded the first week

  • 150+ PIs trained on eSignatures

  • 10,000 eSignatures in the first 6 months

  • OnCore CTMS Integration

  • 41.8% reduction in document cycle time

  • 49.2% acceleration in study startup

  • 12.5% increase in study capacity

  • 6,500 monthly document signatures

  • 580,000+ documents managed in Florence

Integrate with the tools you use every day.

Drive results that matter

Mitigate Risk

Stay inspection-ready with automated audit trails, version control, user permissions, and secure in-app redaction.

Accelerate Timelines

Cut study start-up times by up to 50% and reduce study close-out by two weeks with effortless workflow streamlining.

Increase Capacity

Save 20-30 hours weekly, allowing more focus on patient care and less on administrative tasks.

In clinical research, compliance is crucial. We’ve got you covered globally.

Improve Your Operational Efficiency